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Index > Protein center > Itgav(Gene name) > Mouse
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  • Itgav (Gene name),
  • Integrin alpha-V (Protein name ),  ITAV_MOUSE from NCBI database.
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  • General Annotation
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  • Antigen Annotation
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  • Predicted Eptitope
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  • Vaild Sequence
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  • Gene name:
    Itgav;
    Protein name:
    Integrin alpha-V;
    Alternative:
    Vitronectin receptor subunit alpha;
    CD:
    CD51;
    Organism:
    Mouse (Mus musculus). 
    General Annotation
    Sub Unit:
    Interacts with RAB25 (By similarity). Heterodimer of an alpha and a beta subunit. The alpha subunit is composed of an heavy and a light chain linked by a disulfide bond. Alpha-V associates with either beta-1, beta-3, beta-5, beta-6 or beta-8.
    Function:
    The alpha-V integrins are receptors for vitronectin, cytotactin, fibronectin, fibrinogen, laminin, matrix metalloproteinase-2, osteopontin, osteomodulin, prothrombin, thrombospondin and vWF. They recognize the sequence R-G-D in a wide array of ligands. Alpha-V integrins may play a role in embryo implantation, angiogenesis and wound healing. Mice expressing a null mutation of the alpha-V subunit gene survive until late in embryonic development and occasionally even to birth. They demonstrate cleft palate, and defective development of CNS and gastrointestinal blood vessels.
    Subcellular Location:
    Membrane Single-pass type I membrane protein
    Protein Attributes:
    Sequence length:
    1044
    Sequence:
    50:
    MAAPGRLLLR | PRPGGLLLLL | PGLLLPLADA | FNLDVESPAE | YAGPEGSYFG | 
    100:
    FAVDFFEPST | SSRMFLLVGA | PKANTTQPGI | VEGGQVLKCE | CSSSRRCQPI | 
    150:
    EFDSTGNRDY | AKDDPLEFKS | HQWFGASVRS | KQDKILACAP | LYHWRTEMKQ | 
    200:
    EREPVGTCFL | QDGTKTVEYA | PCRSKNIDAD | GQGFCQGGFS | IDFTKADRVL | 
    250:
    LGGPGSFYWQ | GQLISDQVAE | IISKYDPNVY | SIKYNNQLAT | RTAQAIFDDS | 
    300:
    YLGYSVAVGD | FNGDGIEDFV | SGVPRAARTL | GMVYIYDGKN | MSSLHNFTGE | 
    350:
    QMAAYFGFSV | AATDINGDDY | ADVFIGAPLF | MDRGSDGKLQ | EVGQVSVSLQ | 
    400:
    RAVGDFQTTK | LNGFEVFARF | GSAIAPLGDL | DQDGFNDIAI | AAPYGGEDKK | 
    450:
    GLVYIFNGRS | TGLNSVPSQI | LEGQWAAQSM | PPSFGYSMKG | ATDVDRNGYP | 
    500:
    DLVVGAFGVD | RAVLYRARPV | VTVNAGLEVY | PSILNQDNKI | CPLPGTALKV | 
    550:
    SCFNVRFCLK | ADGKGTLPRK | LHFQVELLLD | KLKQKGAIRR | ALFLHNRSPV | 
    600:
    HSKTMTVFRG | GQMQCEELVA | YLRDESEFRD | KLTPITIFME | YRLDQRTAAD | 
    650:
    ATGLQPILNQ | FTPANVSRQA | HILLDCGEDN | VCKPKLEVSV | NSDQKKIYIG | 
    700:
    DDNPLTLTVK | AQNQGEGAYE | AELIVSIPPQ | ADFIGVVRNN | EALARLSCAF | 
    750:
    KTENQTRQVV | CDLGNPMKAG | TQLLAGLRFS | VHQQSEMDTS | VKFDLKIQSS | 
    800:
    NSFDNVSPVV | SYKVDLAVLA | AVEIRGVSSP | DHIFLPIPNW | EYKENPETEE | 
    850:
    DVGPIVQHIY | ELRNNGPSSF | SKAILNLQWP | YKYNNNTLLY | ILHYDIDGPM | 
    900:
    NCTADTEINP | LRIKTPEKND | TAAAGQGERN | HLITKRDLTL | REGDVHTLGC | 
    950:
    GIAKCLQITC | QVGRLDRGKS | AILYVKSLLW | TETFMNKENQ | NHSYSLKSSA | 
    1000:
    SFNIIEFPYK | NLPIEDLFNS | TLVTTNITWG | IQPAPMPVPV | WVIILAVLAG | 
    1044:
    LLLLAVLVFV | MYRMGFFKRV | RPPQEEQERE | QLQPHENGEG | NSET
    3D Structure:
    N/A
    Predicted Eptitope:
    Please Sign in.
    EIAab Sequence  Vaild Sequence:
    Please Sign in.
    Related Databases
    String:
    UniGene:
    KEGG:
    Pfam:
    SMR:
    Uniprot:
     
    FOR
    ELISA Kit for Mouse Integrin alpha-V
    Cat.:
    E0271h
    Price:
    Please sign in first.
    MSDS:
    Please sign in first.
    Packing:
    96T
    Range:
    Please sign in first.
    ELISA Kit for Mouse Integrin alpha-V
    Cat.:
    E0271b
    Price:
    Please sign in first.
    MSDS:
    Please sign in first.
    Packing:
    96T
    Range:
    Please sign in first.
    ELISA Kit for Mouse Integrin alpha-V
    Cat.:
    E0271m
    Price:
    Please sign in first.
    MSDS:
    Please sign in first.
    Packing:
    96T
    Range:
    Please sign in first.
    ELISA Kit for Mouse Integrin alpha-V
    Cat.:
    E0271c
    Price:
    Please sign in first.
    MSDS:
    Please sign in first.
    Packing:
    96T
    Range:
    Please sign in first.
    CLIA Kit for Mouse Integrin alpha-V
    Cat.:
    U0271c
    Price:
    Please sign in first.
    MSDS:
    Please sign in first.
    Packing:
    96T
    CLIA Kit for Mouse Integrin alpha-V
    Cat.:
    U0271b
    Price:
    Please sign in first.
    MSDS:
    Please sign in first.
    Packing:
    96T
    CLIA Kit for Mouse Integrin alpha-V
    Cat.:
    U0271h
    Price:
    Please sign in first.
    MSDS:
    Please sign in first.
    Packing:
    96T
    CLIA Kit for Mouse Integrin alpha-V
    Cat.:
    U0271m
    Price:
    Please sign in first.
    MSDS:
    Please sign in first.
    Packing:
    96T
    Polyclonal Antibody for Mouse Integrin alpha-V
    Polyclonal Antibody for Mouse Integrin alpha-V
    Cat.:
    P0271Rb-m
    Price:
    Please sign in first.
    Packing:
    40ug/0.2ml
    Polyclonal Antibody for Mouse Integrin alpha-V
    Polyclonal Antibody for Mouse Integrin alpha-V
    Cat.:
    P0271Rb-h
    Price:
    Please sign in first.
    Packing:
    40ug/0.2ml
    Monoclonal Antibody for Mouse Integrin alpha-V
    Monoclonal Antibody for Mouse Integrin alpha-V
    Monoclonal Antibody for Mouse Integrin alpha-V
    Monoclonal Antibody for Mouse Integrin alpha-V
    Protein for Mouse Integrin alpha-V
    Protein for Mouse Integrin alpha-V
    Protein for Mouse Integrin alpha-V
    Protein for Mouse Integrin alpha-V

    R&D Technical Data
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    Precision
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    Recovery
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    Linearity
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    References
    1. 1.
      "Cloning of mouse integrin alphaV cDNA and role of the alphaV-related matrix receptors in metanephric development."
      Wada J. , Kumar A. , Liu Z. , Ruoslahti E. , Reichardt L. , Marvaldi J. , Kanwar Y.S.
      J. Cell Biol.132:1161-1176(1996) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA]
      strain: CD-1.
      tissue: Kidney.
    2. 2.
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]
      strain: C57BL/6J.
    3. 3.
      "The mouse C2C12 myoblast cell surface N-linked glycoproteome: identification, glycosite occupancy, and membrane orientation."
      Gundry R.L. , Raginski K. , Tarasova Y. , Tchernyshyov I. , Bausch-Fluck D. , Elliott S.T. , Boheler K.R. , Van Eyk J.E. , Wollscheid B.
      Mol. Cell. Proteomics8:2555-2569(2009) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: GLYCOSYLATION [LARGE SCALE ANALYSIS] AT ASN-74; ASN-615; ASN-869; ASN-939 AND ASN-941
      tissue: Myoblast.
    4. 4.
      "Mass-spectrometric identification and relative quantification of N-linked cell surface glycoproteins."
      Wollscheid B. , Bausch-Fluck D. , Henderson C. , O'Brien R. , Bibel M. , Schiess R. , Aebersold R. , Watts J.D.
      Nat. Biotechnol.27:378-386(2009) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: GLYCOSYLATION [LARGE SCALE ANALYSIS] AT ASN-74; ASN-615 AND ASN-869
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